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Article

IRS2 takes center stage in the development of type 2 diabetes.

The Journal of clinical investigation - 1 Oct 2004

Brady Matthew J

Abstract excerpt

The etiology of type 2 diabetes is characterized by obesity, insulin and leptin resistance, and compensatory beta cell hyperplasia followed by islet degeneration, resulting in the eventual dysregulation of glucose and lipid homeostasis. The recent identification of insulin receptor substrate 2 (IRS2) as a central player in the pathophysiology of many of these processes suggests a potentially unifying molecular...

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Share to Diabetes Mellitus, Type 2
Share to Insulin
Share to Insulin Receptor Substrate Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Phosphoproteins

Share to Receptor, Insulin

Share to Signal Transduction

Source

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Identifiers

PMID: 15467824
DOI: 10.1172/JCI23108
PMCID: PMC518671

Genes

IRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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