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Article

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

The Journal of clinical investigation - 1 Jan 2000

Kido Y, Burks D J, Withers D, Bruning J C, Kahn C R, White M F, Accili D

Abstract excerpt

Type 2 diabetes is characterized by abnormalities of insulin action in muscle, adipose tissue, and liver and by altered beta-cell function. To analyze the role of the insulin signaling pathway in these processes, we have generated mice with combined heterozygous null mutations in insulin receptor (ir), insulin receptor substrate (irs-1), and/or irs-2. Diabetes developed in 40% of ir/irs-1/irs-2(+/-), 20% of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10642598
DOI: 10.1172/JCI7917
PMCID: PMC377430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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