Article

Cardiomyocyte-specific deletion of PTP1B protects against HFD-induced cardiomyopathy through direct regulation of cardiac metabolic signaling

2023-05-21

Abstract excerpt

<h4>Background</h4> Heart failure is the number one cause of death worldwide and mortality is directly correlated with the high incidence of obesity and diabetes. Indeed, the epidemic phenomenon of obesity was projected to reach 50% in the US by the year 2030. However, the mechanisms linking metabolic dysfunction with heart disease are not clear. Protein Tyrosine Phosphatase 1B (PTP1B), a negative regulator of in...

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Literature Corpus work: ca4bf480-67f4-5295-96f2-3f1c13859fbd
DOI: 10.1101/2023.05.19.541546

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