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Article

Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice.

Journal of hepatology - 1 Feb 2015

Peyrou Marion, Bourgoin Lucie, Poher Anne-Laure, Altirriba Jordi, Maeder Christine, Caillon Aurélie, Fournier Margot, Montet Xavier, Rohner-Jeanrenaud Françoise, Foti Michelangelo

Abstract excerpt

BACKGROUND & AIMS: PTEN is a dual lipid/protein phosphatase, downregulated in steatotic livers with obesity or HCV infection. Liver-specific PTEN knockout (LPTEN KO) mice develop steatosis, inflammation/fibrosis and hepatocellular carcinoma with aging, but surprisingly also enhanced glucose tolerance. This study aimed at understanding the mechanisms by which hepatic PTEN deficiency improves glucose tolerance,...

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Topics

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Share to Adipose Tissue
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glucose Tolerance Test

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Share to PTEN Phosphohydrolase

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Source

Identifiers

PMID: 25234947
DOI: 10.1016/j.jhep.2014.09.012

Genes

PTEN
FGF21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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