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Article

Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2015

Schultze Simon M, Dietrich Maren, Hynx Debby, Geier Andreas, Niessen Markus, Spinas Giatgen A, Hemmings Brian A, Tschopp Oliver

Abstract excerpt

BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is a major health problem and occurs frequently in the context of metabolic syndrome and type 2 diabetes mellitus. Hepatocyte-specific Pten-deficiency in mice was shown previously to result in hepatic steatosis due to hyperactivated AKT2. However, the role of peripheral insulin-sensitive tissues on PTEN- and AKT2-dependent accumulation of hepatic lipids...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

Identifiers

PMID: 24845341
DOI: 10.1111/liv.12600

Genes

AKT2
PTEN

Provenance

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