Article
Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling.
PloS one - 21 Dec 2009
Hinoue Toshinori, Weisenberger Daniel J, Pan Fei, Campan Mihaela, Kim Myungjin, Young Joanne, Whitehall Vicki L, Leggett Barbara A, Laird Peter W
Abstract excerpt
A CpG island methylator phenotype (CIMP) is displayed by a distinct subset of colorectal cancers with a high frequency of DNA hypermethylation in a specific group of CpG islands. Recent studies have shown that an activating mutation of BRAF (BRAF(V600E)) is tightly associated with CIMP, raising the question of whether BRAF(V600E) plays a causal role in the development of CIMP or whether CIMP provides a favorable...
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