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Article

Genome-scale analysis of aberrant DNA methylation in colorectal cancer.

Genome research - 1 Feb 2012

Hinoue Toshinori, Weisenberger Daniel J, Lange Christopher P E, Shen Hui, Byun Hyang-Min, Van Den Berg David, Malik Simeen, Pan Fei, Noushmehr Houtan, van Dijk Cornelis M, Tollenaar Rob A E M, Laird Peter W

Abstract excerpt

Colorectal cancer (CRC) is a heterogeneous disease in which unique subtypes are characterized by distinct genetic and epigenetic alterations. Here we performed comprehensive genome-scale DNA methylation profiling of 125 colorectal tumors and 29 adjacent normal tissues. We identified four DNA methylation-based subgroups of CRC using model-based cluster analyses. Each subtype shows characteristic genetic and...

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Identifiers

PMID: 21659424
DOI: 10.1101/gr.117523.110
PMCID: PMC3266034

Genes

BRAF
KRAS
MLH1

Variants

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Source receipt: pubmed, retrieved 7 Sept 2026.

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