Article
Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features.
BMC cancer - 21 May 2010
Ang Pei Woon, Loh Marie, Liem Natalia, Lim Pei Li, Grieu Fabienne, Vaithilingam Aparna, Platell Cameron, Yong Wei Peng, Iacopetta Barry, Soong Richie
Abstract excerpt
BACKGROUND: Most previous studies of the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been conducted on a relatively small numbers of CpG sites. In the present study we performed comprehensive DNA methylation profiling of CRC with the aim of characterizing CIMP subgroups. METHODS: DNA methylation at 1,505 CpG sites in 807 cancer-related genes was evaluated using the Illumina GoldenGate...
Topics
- Adult
- Age Factors
- Aged
- Cluster Analysis
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic