Article
Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features.
BMC cancer - 21 May 2010
Ang Pei Woon, Loh Marie, Liem Natalia, Lim Pei Li, Grieu Fabienne, Vaithilingam Aparna, Platell Cameron, Yong Wei Peng, Iacopetta Barry, Soong Richie
Abstract excerpt
BACKGROUND: Most previous studies of the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been conducted on a relatively small numbers of CpG sites. In the present study we performed comprehensive DNA methylation profiling of CRC with the aim of characterizing CIMP subgroups. METHODS: DNA methylation at 1,505 CpG sites in 807 cancer-related genes was evaluated using the Illumina GoldenGate...
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