Article
Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype.
The American journal of pathology - 1 Nov 2012
Yamamoto Eiichiro, Suzuki Hiromu, Yamano Hiro-o, Maruyama Reo, Nojima Masanori, Kamimae Seiko, Sawada Takeshi, Ashida Masami, Yoshikawa Kenjiro, Kimura Tomoaki, Takagi Ryo, Harada Taku, Suzuki Ryo, Sato Akiko, Kai Masahiro, Sasaki Yasushi, Tokino Takashi, Sugai Tamotsu, Imai Kohzoh, Shinomura Yasuhisa, Toyota Minoru
Abstract excerpt
The concept of the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) is widely accepted, although the timing of its occurrence and its interaction with other genetic defects are not fully understood. Our aim in this study was to unravel the molecular development of CIMP cancers by dissecting their genetic and epigenetic signatures in precancerous and malignant colorectal lesions. We characterized...
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