Article
Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2008
English Dallas R, Young Joanne P, Simpson Julie A, Jenkins Mark A, Southey Melissa C, Walsh Michael D, Buchanan Daniel D, Barker Melissa A, Haydon Andrew M, Royce Simon G, Roberts Aedan, Parry Susan, Hopper John L, Jass Jeremy J, Giles Graham G
Abstract excerpt
Colorectal cancers arising from serrated polyps are characterized by the CpG island methylator phenotype (CIMP) and somatic mutation (V600E) in the BRAF proto-oncogene. Few epidemiologic studies have investigated risk factors for these tumors. We conducted a cohort study of 41,328 residents of Melbourne, Australia that included 9,939 participants of southern European origin and 31,389 of Anglo-Celtic origin....
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