Article
Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations.
Oncotarget - 7 Jun 2016
Sawada Takeshi, Yamamoto Eiichiro, Yamano Hiro-O, Nojima Masanori, Harada Taku, Maruyama Reo, Ashida Masami, Aoki Hironori, Matsushita Hiro-O, Yoshikawa Kenjiro, Harada Eiji, Tanaka Yoshihito, Wakita Shigenori, Niinuma Takeshi, Kai Masahiro, Eizuka Makoto, Sugai Tamotsu, Suzuki Hiromu
Abstract excerpt
To clarify the molecular and clinicopathological characteristics of colorectal serrated lesions, we assessed the DNA methylation of cancer-associated genes in a cohort of BRAF-mutant precancerous lesions from 94 individuals. We then compared those results with the lesions' clinicopathological features, especially colorectal subsites. The lesions included hyperplastic polyps (n = 16), traditional serrated adenomas...
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