Article
Profile of TP53 gene mutations in sinonasal cancer.
Mutation research - 1 Apr 2010
Holmila Reetta, Bornholdt Jette, Suitiala Tuula, Cyr Diane, Dictor Michael, Steiniche Torben, Wolff Henrik, Wallin Håkan, Luce Danièle, Husgafvel-Pursiainen Kirsti
Abstract excerpt
Genetic alterations underlying the development of the cancer of the nose and paranasal sinuses (sinonasal cancer, SNC), a rare cancer that can be included in the group of head and neck cancers, are still largely unknown. We recently reported that TP53 mutations are a common feature of SNC, with an overall frequency of 77%, and they show association to adenocarcinoma and wood-dust exposure [15]. In this study, we...
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