Article
Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2005
Yom Sue S, Rashid Asif, Rosenthal David I, Elliott Danielle D, Hanna Ehab Y, Weber Randal S, El-Naggar Adel K
Abstract excerpt
Sinonasal adenocarcinomas, a relatively rare entity, are composed of distinctly different morphologic subtypes with variable biological behavior. To investigate the genetic events associated with their development and clinicopathologic features, we analyzed the alterations in K-ras, APC, beta-catenin, hMLH1 and hMSH2 and p53 genes expression in a cohort of 15 primary tumors comprising the two main sinonasal...
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