Article
TP53, p14ARF, p16INK4a and H-ras gene molecular analysis in intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses.
International journal of cancer - 10 Jun 2003
Perrone Federica, Oggionni Maria, Birindelli Sarah, Suardi Simona, Tabano Silvia, Romano Roberta, Moiraghi Maria Luisa, Bimbi Gabriella, Quattrone Pasquale, Cantu Giulio, Pierotti Marco A, Licitra Lisa, Pilotti Silvana
Abstract excerpt
Intestinal-type adenocarcinoma (ITAC) of the nasal cavity and paranasal sinuses is an uncommon tumor associated with occupational exposure to dusts of different origin. Few investigations addressed molecular alterations in ITAC mainly focused on TP53, K-ras and H-ras gene mutations. The occurrence of TP53, p14(ARF) and p16(INK4a) deregulation and H-ras mutations was investigated in 21 consecutive and untreated...
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