Article
The spectrum of mutations in TP53 in laryngeal cancer patients from a high-incidence population shows similarities to many of the known mutational hotspots.
Cancer genetics and cytogenetics - 1 Sept 2003
Barnard Desiré, Lehmann Karen, Hoal Eileen G, van Helden Paul D, Victor Thomas C
Abstract excerpt
Laryngeal cancer (LC) is the sixth most common cancer in the world and the second most common respiratory cancer, with approximately 500000 new cases worldwide, annually. The mechanisms of tumorigenesis in LC remain unknown, although smoking and alcohol consumption are considered to be major risk factors. Mutations within TP53 have been strongly implicated as frequent events in several cancers. We screened exons...
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