Article
Mutations in TP53 tumor suppressor gene in wood dust-related sinonasal cancer.
International journal of cancer - 1 Aug 2010
Holmila Reetta, Bornholdt Jette, Heikkilä Pirjo, Suitiala Tuula, Févotte Joëlle, Cyr Diane, Hansen Johnni, Snellman Satu-Marja, Dictor Michael, Steiniche Torben, Schlünssen Vivi, Schneider Thomas, Pukkala Eero, Savolainen Kai, Wolff Henrik, Wallin Håkan, Luce Danièle, Husgafvel-Pursiainen Kirsti
Abstract excerpt
The causal role of work-related exposure to wood dust in the development of sinonasal cancer has long been established by numerous epidemiologic studies. To study molecular changes in these tumors, we analyzed TP53 gene mutations in 358 sinonasal cancer cases with or without occupational exposure to wood dust, using capillary electrophoresis single-strand conformation polymorphism analysis and direct sequencing....
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