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Article

Wood dust-related mutational profile of TP53 in intestinal-type sinonasal adenocarcinoma.

Human pathology - 1 Nov 2012

Pérez-Escuredo Jhudit, Martínez Jorge García, Vivanco Blanca, Marcos César Álvarez, Suárez Carlos, Llorente José Luis, Hermsen Mario A

Abstract excerpt

Intestinal-type sinonasal adenocarcinoma represents 8% to 25% of all malignant sinonasal cancer and is etiologically related to occupational exposure to wood dust. Despite its clear etiology, the mechanisms behind the carcinogenic effects of wood dust are unclear. Because it is known that carcinogens can leave specific mutational fingerprints, we aimed to analyze the spectrum of TP53 mutations and to relate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22575263
DOI: 10.1016/j.humpath.2012.01.016

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