Article
Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.
Developmental biology - 15 Jan 2010
Ikeya Makoto, Fukushima Kumi, Kawada Masako, Onishi Sachiko, Furuta Yasuhide, Yonemura Shigenobu, Kitamura Toshio, Nosaka Tetsuya, Sasai Yoshiki
Abstract excerpt
The fine-tuning of BMP signals is critical for many aspects of complex organogenesis. In this report, we show that the augmentation of BMP signaling by a BMP-binding secreted factor, Crossveinless2 (Cv2), is essential for the early embryonic development of mammalian nephrons. In the Cv2-null mouse, the number of cap condensates (clusters of nephron progenitors, which normally express Cv2) was decreased, and the...
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