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The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation

14 Sept 2010

Abstract excerpt

The planar cell polarity (PCP) pathway, incorporating non-canonical Wnt signalling, controls embryonic convergent (CE) extension, polarized cell division and ciliary orientation. It also limits diameters of differentiating renal tubules, with mutation of certain components of the pathway causing cystic kidneys. Mutations in mouse Vangl genes encoding core PCP proteins cause neural tube defects (NTDs) and Vangl2...

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PMID: 20843830
DOI: 10.1093/hmg/ddq397

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