Article
The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila.
Developmental cell - 1 Jun 2008
Serpe Mihaela, Umulis David, Ralston Amy, Chen Jun, Olson David J, Avanesov Andrei, Othmer Hans, O'Connor Michael B, Blair Seth S
Abstract excerpt
In Drosophila, the secreted BMP-binding protein Short gastrulation (Sog) inhibits signaling by sequestering BMPs from receptors, but enhances signaling by transporting BMPs through tissues. We show that Crossveinless 2 (Cv-2) is also a secreted BMP-binding protein that enhances or inhibits BMP signaling. Unlike Sog, however, Cv-2 does not promote signaling by transporting BMPs. Rather, Cv-2 binds cell surfaces...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.