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Article

Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation.

Development (Cambridge, England) - 1 Mar 2006

Rentzsch Fabian, Zhang Jinli, Kramer Carina, Sebald Walter, Hammerschmidt Matthias

Abstract excerpt

Signaling by bone morphogenetic proteins (Bmps) plays a pivotal role in developmental and pathological processes, and is regulated by a complex interplay with secreted Bmp binding factors, including Crossveinless 2 (Cvl2). Although structurally related to the Bmp antagonist Chordin, Crossveinless 2 has been described to be both a Bmp agonist and antagonist. Here, we present the first loss-of-function study of a...

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Source

Identifiers

PMID: 16439480
DOI: 10.1242/dev.02250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation.PMID 16439480Read ↗

Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.Semantic proximity Read ↗

Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins.Semantic proximity Read ↗

Crystal Structure Analysis Reveals How the Chordin Family Member Crossveinless 2 Blocks BMP-2 Receptor BindingSemantic proximity Read ↗

The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila.Semantic proximity Read ↗

Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos.Semantic proximity Read ↗

Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation.Semantic proximity Read ↗

Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila.Semantic proximity Read ↗

Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.Semantic proximity Read ↗

crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling.Semantic proximity Read ↗

Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice.Semantic proximity Read ↗

Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wing.Semantic proximity Read ↗

Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.Semantic proximity Read ↗

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