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PAX2 Activates WNT4 Expression during Mammalian Kidney Development

21 Dec 2005

Abstract excerpt

The transcription factor PAX2 is expressed during normal kidney development and is thought to influence outgrowth and branching of the ureteric bud. Mice with homozygous null Pax2 mutations have developmental defects of the midbrain-hindbrain region, optic nerve, and ear and are anephric. During nephrogenesis, PAX2 is also expressed by mesenchymal cells as they cluster and reorganize to form proximal elements of...

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PMID: 16368682
DOI: 10.1074/jbc.m513181200

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