Article
Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.
Development (Cambridge, England) - 1 Nov 2006
Ikeya Makoto, Kawada Masako, Kiyonari Hiroshi, Sasai Noriaki, Nakao Kazuki, Furuta Yasuhide, Sasai Yoshiki
Abstract excerpt
We here report essential roles of the Bmp-binding protein crossveinless 2 (Cv2; Bmper) in mouse organogenesis. In the null Cv2 mutant mouse, gastrulation occurs normally, but a number of defects are found in Cv2-expressing tissues such as the skeleton. Cartilage differentiation by Bmp4 treatment is reduced in cultured Cv2(-/-) fibroblasts. Moreover, the defects in the vertebral column and eyes of the Cv2(-/-)...
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