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Article

Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation.

Developmental biology - 1 Nov 2008

Zakin Lise, Metzinger Carrie A, Chang Ellen Y, Coffinier Catherine, De Robertis E M

Abstract excerpt

Crossveinless-2 (Cv2), Twisted Gastrulation (Tsg) and Chordin (Chd) are components of an extracellular biochemical pathway that regulates Bone Morphogenetic Protein (BMP) activity during dorso-ventral patterning of Drosophila and Xenopus embryos, the formation of the fly wing, and mouse skeletogenesis. Because the nature of their genetic interactions remained untested in the mouse, we generated a null allele for...

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Source

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Identifiers

PMID: 18789316
DOI: 10.1016/j.ydbio.2008.08.019
PMCID: PMC2647368

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation.PMID 18789316Read ↗

Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos.Semantic proximity Read ↗

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crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling.Semantic proximity Read ↗

Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.Semantic proximity Read ↗

Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation.Semantic proximity Read ↗

Crystal Structure Analysis Reveals How the Chordin Family Member Crossveinless 2 Blocks BMP-2 Receptor BindingSemantic proximity Read ↗

Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain developmentSemantic proximity Read ↗

The pro-BMP activity of Twisted gastrulation is independent of BMP binding.Semantic proximity Read ↗

The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila.Semantic proximity Read ↗

Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins.Semantic proximity Read ↗

Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning.Semantic proximity Read ↗

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