PAX genes in development and disease: the role of PAX2 in urogenital tract development.

Abstract excerpt

PAX genes play an important role in fetal development. Moreover, heterozygous mutations in several PAX genes cause human disease. Here we review the role of PAX2 in kidney development, focusing on the morphological effects of PAX2 mutations. We discuss the role of PAX2 in the context of an inhibitory field model of kidney branching morphogenesis and summarize recent progress in this area.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis
• Share to Coloboma
• Share to Gene Expression Regulation, Developmental