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Article

Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis.

Biological psychiatry - 15 May 2007

McIntosh Andrew M, Baig Ben J, Hall Jeremy, Job Dominic, Whalley Heather C, Lymer G Katherine S, Moorhead T William J, Owens David G C, Miller Patrick, Porteous David, Lawrie Stephen M, Johnstone Eve C

Abstract excerpt

BACKGROUND: There is growing evidence that the gene catechol-O-methyltransferase (COMT) is involved in the etiopathogenesis of schizophrenia. This study sought to clarify the effects of the COMT Val158Met polymorphism on brain structure, function, and risk of developing schizophrenia in a well-characterized cohort of individuals at high risk of schizophrenia for familial reasons. METHODS: In a sample of 78 people...

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Source

Identifiers

PMID: 17014827
DOI: 10.1016/j.biopsych.2006.05.020

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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