MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met.

doi:10.1073/pnas.0803727105

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Article

MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2008

Roffman Joshua L, Gollub Randy L, Calhoun Vince D, Wassink Thomas H, Weiss Anthony P, Ho Beng C, White Tonya, Clark Vincent P, Fries Jill, Andreasen Nancy C, Goff Donald C, Manoach Dara S

Abstract excerpt

Understanding how risk genes cumulatively impair brain function in schizophrenia could provide critical insights into its pathophysiology. Working memory impairment in schizophrenia has been associated with abnormal dopamine signaling in the prefrontal cortex, which is likely under complex genetic control. The catechol-O-methyltransferase (COMT) 158Val --> Met polymorphism (rs4680), which affects the availability...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18988738
DOI: 10.1073/pnas.0803727105
PMCID: PMC2582272

Genes

COMT
MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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