Article
Association between catechol-O-methyltrasferase Val108/158Met genotype and prefrontal hemodynamic response in schizophrenia.
PloS one - 1 Jan 2009
Takizawa Ryu, Tochigi Mamoru, Kawakubo Yuki, Marumo Kohei, Sasaki Tsukasa, Fukuda Masato, Kasai Kiyoto
Abstract excerpt
BACKGROUND: "Imaging genetics" studies have shown that brain function by neuroimaging is a sensitive intermediate phenotype that bridges the gap between genes and psychiatric conditions. Although the evidence of association between functional val108/158met polymorphism of the catechol-O-methyltransferase gene (COMT) and increasing risk for developing schizophrenia from genetic association studies remains to be...
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