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Article

Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance.

Psychiatry research - 30 Oct 2006

Bertolino Alessandro, Caforio Grazia, Petruzzella Vittoria, Latorre Valeria, Rubino Valeria, Dimalta Savino, Torraco Alessandra, Blasi Giuseppe, Quartesan Roberto, Mattay Venkata S, Callicott Joseph H, Weinberger Daniel R, Scarabino Tommaso

Abstract excerpt

Earlier studies with functional imaging in schizophrenia have demonstrated dysfunction of the dorsolateral prefrontal cortex during working memory. Controlling for behavioral performance and for catechol-O-methyltransferase (COMT) Val158Met genotype, we here demonstrate in a functional magnetic resonance imaging paradigm that patients recruit greater neuronal resources in prefrontal cortex during working memory,...

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Source

Identifiers

PMID: 16952445
DOI: 10.1016/j.pscychresns.2006.04.001

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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