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Article

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2001

Egan M F, Goldberg T E, Kolachana B S, Callicott J H, Mazzanti C M, Straub R E, Goldman D, Weinberger D R

Abstract excerpt

Abnormalities of prefrontal cortical function are prominent features of schizophrenia and have been associated with genetic risk, suggesting that susceptibility genes for schizophrenia may impact on the molecular mechanisms of prefrontal function. A potential susceptibility mechanism involves regulation of prefrontal dopamine, which modulates the response of prefrontal neurons during working memory. We examined...

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Identifiers

PMID: 11381111
DOI: 10.1073/pnas.111134598
PMCID: PMC34453

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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