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Article

Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest.

NeuroImage - 1 Mar 2013

Tunbridge Elizabeth M, Farrell Sarah M, Harrison Paul J, Mackay Clare E

Abstract excerpt

Catechol-O-methyltransferase (COMT) modulates dopamine in the prefrontal cortex (PFC) and influences PFC dopamine-dependent cognitive task performance. A human COMT polymorphism (Val(158)Met) alters enzyme activity and is associated with both the activation and functional connectivity of the PFC during task performance, particularly working memory. Here, we used functional magnetic resonance imaging and a...

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Identifiers

PMID: 23228511
DOI: 10.1016/j.neuroimage.2012.11.059
PMCID: PMC3566589

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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