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Article

Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia.

Biological psychiatry - 15 Mar 2009

Prata Diana P, Mechelli Andrea, Fu Cynthia H Y, Picchioni Marco, Kane Fergus, Kalidindi Sridevi, McDonald Colm, Howes Oliver, Kravariti Eugenia, Demjaha Arsime, Toulopoulou Timothea, Diforti Marta, Murray Robin M, Collier David A, McGuire Philip K

Abstract excerpt

BACKGROUND: Catechol-O-methyltransferase (COMT) is essential for dopamine metabolism in the brain, and normal variation in the COMT Val158Met polymorphism can influence regional brain function during cognitive tasks. How this is affected when central dopamine function is perturbed is unclear. We...

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Identifiers

PMID: 19054502
DOI: 10.1016/j.biopsych.2008.09.027

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19054502-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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