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Article

The catechol‐O‐methyltransferase (COMT) Val158Met genotype modulates working memory‐related dorsolateral prefrontal response and performance in bipolar disorder

1 May 2017

Abstract excerpt

OBJECTIVES: Cognitive dysfunction affects a substantial proportion of patients with bipolar disorder (BD), and genetic-imaging paradigms may aid in the elucidation of mechanisms implicated in this symptomatic domain. The Val allele of the functional Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene is associated with reduced prefrontal cortex dopamine and exaggerated working memory-related...

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PMID: 28544426
DOI: 10.1111/bdi.12497

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