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Article

Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia.

The American journal of psychiatry - 1 Oct 2004

Bertolino Alessandro, Caforio Grazia, Blasi Giuseppe, De Candia Mariapia, Latorre Valeria, Petruzzella Vittoria, Altamura Mario, Nappi Gaetano, Papa Sergio, Callicott Joseph H, Mattay Venkata S, Bellomo Antonello, Scarabino Tommaso, Weinberger Daniel R, Nardini Marcello

Abstract excerpt

OBJECTIVE: Deficits in working memory and in prefrontal cortical physiology are important outcome measures in schizophrenia, and both have been associated with dopamine dysregulation and with a functional polymorphism (Val(108/158)Met) in the catechol O-methyltransferase (COMT) gene that affects...

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Source

Identifiers

PMID: 15465976
DOI: 10.1176/ajp.161.10.1798

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15465976-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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