Article
P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels.
PloS one - 5 Nov 2009
D'Avanzo Nazzareno, Pekhletski Roman, Backx Peter H
Abstract excerpt
HCN channels are thought to be structurally similar to Kv channels, but show much lower selectivity for K+. The approximately 3.3 A selectivity filter of K+ channels is formed by the pore-lining sequence XT(V/I)GYG, with X usually T, and is held stable by key residues in the P-loop. Differences in the P-loop sequence of HCN channels (eg. the pore-lining sequence L478C479IGYG) suggest these residues could account...
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