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Article

Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore.

The Journal of general physiology - 1 Apr 1997

Tsushima R G, Li R A, Backx P H

Abstract excerpt

To explore the role of pore-lining amino acids in Na+ channel ion-selectivity, pore residues were replaced serially with cysteine in cloned rat skeletal muscle Na+ channels. Ionic selectivity was determined by measuring permeability and ionic current ratios of whole-cell currents in Xenopus oocytes. The rSkM1 channels displayed an ionic selectivity sequence Na+ > Li+ > NH4+ > > Cs+ and were impermeable to...

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Identifiers

PMID: 9101405
DOI: 10.1085/jgp.109.4.463
PMCID: PMC2219431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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