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Article

Separable gating mechanisms in a Mammalian pacemaker channel.

The Journal of biological chemistry - 27 Sept 2002

Macri Vincenzo, Proenza Catherine, Agranovich Eugene, Angoli Damiano, Accili Eric A

Abstract excerpt

Despite permeability to both K(+) and Na(+), hyperpolarization-activated cyclic nucleotide-gated (HCN) pacemaker channels contain the K(+) channel signature sequence, GYG, within the selectivity filter of the pore. Here, we show that this region is involved in regulating gating in a mouse isoform...

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Identifiers

PMID: 12121985
DOI: 10.1074/jbc.M203485200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12121985-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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