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Article

Observation of σ-pore currents in mutant hKv1.2_V370C potassium channels.

PloS one - 1 Jan 2017

Tyutyaev Pavel, Grissmer Stephan

Abstract excerpt

Current through the σ-pore was first detected in hKv1.3_V388C channels, where the V388C mutation in hKv1.3 channels opened a new pathway (σ-pore) behind the central α-pore. Typical for this mutant channel was inward current at potentials more negative than -100 mV when the central α-pore was closed. The α-pore blockers such as TEA+ and peptide toxins (CTX, MTX) could not reduce current through the σ-pore of...

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Identifiers

PMID: 28426823
DOI: 10.1371/journal.pone.0176078
PMCID: PMC5398642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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