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Article

Structural insight into Ca2+ specificity in tetrameric cation channels.

Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2007

Alam Amer, Shi Ning, Jiang Youxing

Abstract excerpt

Apparent blockage of monovalent cation currents by the permeating blocker Ca(2+) is a physiologically essential phenomenon relevant to cyclic nucleotide-gated (CNG) channels. The recently determined crystal structure of a bacterial homolog of CNG channel pores, the NaK channel, revealed a Ca(2+) binding site at the extracellular entrance to the selectivity filter. This site is not formed by the side-chain...

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Identifiers

PMID: 17878296
DOI: 10.1073/pnas.0707324104
PMCID: PMC2000519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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