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Article

Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.

American journal of physiology. Cell physiology - 1 Aug 2008

Vemana Sriharsha, Pandey Shilpi, Larsson H Peter

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are activated by membrane hyperpolarization that creates time-dependent, inward rectifying currents, gated by the movement of the intrinsic voltage sensor S4. However, inward rectification of the HCN currents is not only observed in the time-dependent HCN currents, but also in the instantaneous HCN tail currents. Inward rectification can also be...

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Source

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Identifiers

PMID: 18579800
DOI: 10.1152/ajpcell.00154.2008
PMCID: PMC2518427

Genes

HCN1
HCN2
HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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