Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extracellular histidine residues crucial for Na+ self-inhibition of epithelial Na+ channels.

The Journal of biological chemistry - 12 Mar 2004

Sheng Shaohu, Bruns James B, Kleyman Thomas R

Abstract excerpt

Epithelial Na(+) channels (ENaC) participate in the regulation of extracellular fluid volume homeostasis and blood pressure. Channel activity is regulated by both extracellular and intracellular Na(+). The down-regulation of ENaC activity by external Na(+) is referred to as Na(+) self-inhibition. We investigated the structural determinants of Na(+) self-inhibition by expressing wild-type or mutant ENaCs in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down-Regulation
Share to Histidine
Share to Oocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Patch-Clamp Techniques

Share to Protein Structure, Secondary

Share to Sodium

Share to Sodium Channels

Share to Xenopus

Source

Identifiers

PMID: 14701851
DOI: 10.1074/jbc.M311952200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extracellular histidine residues crucial for Na+ self-inhibition of epithelial Na+ channels.PMID 14701851Read ↗

Novel determinants of epithelial sodium channel gating within extracellular thumb domains.Semantic proximity Read ↗

Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain.Semantic proximity Read ↗

Identification of extracellular domain residues required for epithelial Na+ channel activation by acidic pH.Semantic proximity Read ↗

External nickel inhibits epithelial sodium channel by binding to histidine residues within the extracellular domains of alpha and gamma subunits and reducing channel open probability.Semantic proximity Read ↗

Extracellular protons regulate human ENaC by modulating Na+ self-inhibition.Semantic proximity Read ↗

The epithelial sodium channel (ENaC): new insights into ENaC gating.Semantic proximity Read ↗

Na+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleft.Semantic proximity Read ↗

Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels.Semantic proximity Read ↗

Varying selection pressure for a Na <sup>+</sup> sensing site in epithelial Na <sup>+</sup> channel subunits reflect divergent roles in Na <sup>+</sup> homeostasisSemantic proximity Read ↗

Asymmetric organization of the pore region of the epithelial sodium channel.Semantic proximity Read ↗

A Missense Mutation in the Extracellular Domain of αENaC Causes Liddle SyndromeSemantic proximity Read ↗

Opposite effects of Ni2+ on Xenopus and rat ENaCs expressed in Xenopus oocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.