Article

Two serial filters determine P2X7R cation selectivity, Ser342 in the central pore and lateral acidic residues at the cytoplasmic interface

2024-02-19

Abstract excerpt

The human P2X7R (hP2X7R) is a homotrimeric cell surface receptor gated by extracellular ATP4- with two transmembrane helices per subunit, TM1 and TM2. A ring of three S342 residues, one from each pore-forming TM2 helix, located halfway across the membrane bilayer, functions to close and open the gate in the apo and ATP4- bound open states, respectively. The hP2X7R is selective for small inorganic cations, but can...

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Literature Corpus work: 4aaec734-44e1-5108-a21a-e811fa9a4c99
DOI: 10.1101/2024.02.19.579953

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