Article
Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011
Derebe Mehabaw G, Sauer David B, Zeng Weizhong, Alam Amer, Shi Ning, Jiang Youxing
Abstract excerpt
Selective ion conduction across ion channel pores is central to cellular physiology. To understand the underlying principles of ion selectivity in tetrameric cation channels, we engineered a set of cation channel pores based on the nonselective NaK channel and determined their structures to high resolution. These structures showcase an ensemble of selectivity filters with a various number of contiguous ion...
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