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Article

The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.

Science signaling - 3 Nov 2009

Ashique Amir M, Choe Youngshik, Karlen Mattias, May Scott R, Phamluong Khanhky, Solloway Mark J, Ericson Johan, Peterson Andrew S

Abstract excerpt

Regulatory factor X (Rfx) homologs regulate the transcription of genes necessary for ciliogenesis in invertebrates and vertebrates. Primary cilia are necessary for Hedgehog signaling and regulation of the activity of the transcriptional regulators known as Gli proteins, which are targets of Hedgehog signaling. Here, we describe an Rfx4(L298P) mouse mutant with distinct dorsoventral patterning defects in the...

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Source

Identifiers

PMID: 19887680
DOI: 10.1126/scisignal.2000602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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