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Article

The primary cilium as a Hedgehog signal transduction machine.

Methods in cell biology - 1 Jan 2009

Goetz Sarah C, Ocbina Polloneal J R, Anderson Kathryn V

Abstract excerpt

The Hedgehog (Hh) signal transduction pathway is essential for the development and patterning of numerous organ systems, and has important roles in a variety of human cancers. Genetic screens for mouse embryonic patterning mutants first showed a connection between mammalian Hh signaling and intraflagellar transport (IFT), a process required for construction of the primary cilium, a small cellular projection found...

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Identifiers

PMID: 20362092
DOI: 10.1016/S0091-679X(08)94010-3
PMCID: PMC2867239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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