Article
The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon.
Human molecular genetics - 1 May 2015
Magnani Dario, Morlé Laurette, Hasenpusch-Theil Kerstin, Paschaki Marie, Jacoby Monique, Schurmans Stéphane, Durand Bénédicte, Theil Thomas
Abstract excerpt
Primary cilia are complex subcellular structures that play key roles during embryogenesis by controlling the cellular response to several signaling pathways. Defects in the function and/or structure of primary cilia underlie a large number of human syndromes collectively referred to as ciliopathies. Often, ciliopathies are associated with mental retardation (MR) and malformation of the corpus callosum. However,...
Topics
- Animals
- Body Patterning
- Cerebral Cortex
- DNA-Binding Proteins
- Embryo, Mammalian
- Homozygote
- Immunohistochemistry
- Kruppel-Like Transcription Factors
- Mice
- Mutation
- Nerve Tissue Proteins
- Neural Pathways
- Neurons