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Article

Generation of mice with a conditional allele for Ift172.

Transgenic research - 1 Feb 2010

Howard Paul W, Howard Tiffani L, Maurer Richard A

Abstract excerpt

Ift172 encodes a gene product that is part of a complex that mediates intraflagellar transport (IFT), a process necessary for the genesis and maintenance of cilia. Genetic studies in mice have offered evidence that Ift172 also plays a role in hedgehog signaling. Disruption of Ift172 in mice is associated with lethality at about embryonic day 11, limiting studies to understand the role for Ift172 in later...

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Share to Adaptor Proteins, Signal Transducing
Share to Cytoskeletal Proteins
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Transfer Techniques

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Share to Intracellular Signaling Peptides and Proteins

Share to Limb Deformities, Congenital

Source

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Identifiers

PMID: 19521792
DOI: 10.1007/s11248-009-9292-x
PMCID: PMC2806820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Generation of mice with a conditional allele for Ift172.PMID 19521792Read ↗

Ift172 conditional knock-out mice exhibit rapid retinal degeneration and protein trafficking defects.Semantic proximity Read ↗

Cilia and Hedgehog responsiveness in the mouse.Semantic proximity Read ↗

Analysis of hedgehog signaling in mouse intraflagellar transport mutants.Semantic proximity Read ↗

<i>Ift172</i> conditional knockout mice exhibit rapid retinal degeneration and protein trafficking defectsSemantic proximity Read ↗

Deletion of IFT80 Impairs Epiphyseal and Articular Cartilage Formation Due to Disruption of Chondrocyte DifferentiationSemantic proximity Read ↗

A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.Semantic proximity Read ↗

Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain.Semantic proximity Read ↗

An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of ciliaSemantic proximity Read ↗

Hedgehog signalling in the mouse requires intraflagellar transport proteins.Semantic proximity Read ↗

The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.Semantic proximity Read ↗

Murine germ cell-specific disruption of Ift172 causes defects in spermiogenesis and male fertilitySemantic proximity Read ↗

Cauli: a mouse strain with an Ift140 mutation that results in a skeletal ciliopathy modelling Jeune syndrome.Semantic proximity Read ↗

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