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Article

Ftm is a novel basal body protein of cilia involved in Shh signalling.

Development (Cambridge, England) - 1 Jul 2007

Vierkotten Jeanette, Dildrop Renate, Peters Thomas, Wang Baolin, Rüther Ulrich

Abstract excerpt

In this study we show in mice that Ftm (Rpgrip1l) is located at the ciliary basal body. Our data reveal that Ftm is necessary for developmental processes such as the establishment of left-right asymmetry and patterning of the neural tube and the limbs. The loss of Ftm affects the ratio of Gli3 activator to Gli3 repressor, suggesting an involvement of Ftm in Shh signalling. As Ftm is not essential for cilia...

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Identifiers

PMID: 17553904
DOI: 10.1242/dev.003715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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