Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain.

Developmental biology - 1 Nov 2009

Stottmann R W, Tran P V, Turbe-Doan A, Beier D R

Abstract excerpt

Organizing centers in the developing brain provide an assortment of instructive patterning cues, including Sonic hedgehog (Shh). Here we characterize the forebrain phenotype caused by loss of Ttc21b, a gene we identified in an ENU mutagenesis screen as a novel ciliary gene required for retrograde...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Fibroblast Growth Factor 8
Share to Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to Morphogenesis

Share to Prosencephalon

Share to Wnt Proteins

Share to Zinc Finger Protein Gli3

Source

Open in PubMed Open full text

Identifiers

PMID: 19732765
DOI: 10.1016/j.ydbio.2009.08.023
PMCID: PMC2778284

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19732765-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain.PMID 19732765Read ↗

Perdurant TTC21B protein in the early mouse embryo is required for proper forebrain neural progenitor proliferationSemantic proximity Read ↗

Analysis of hedgehog signaling in mouse intraflagellar transport mutants.Semantic proximity Read ↗

Disruption of Fuz in mouse embryos generates hypoplastic hindbrain development and reduced cranial nerve gangliaSemantic proximity Read ↗

Cauli: a mouse strain with an Ift140 mutation that results in a skeletal ciliopathy modelling Jeune syndrome.Semantic proximity Read ↗

<i>Zfp423</i> regulates Sonic hedgehog signaling via primary cilium functionSemantic proximity Read ↗

Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.Semantic proximity Read ↗

Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse.Semantic proximity Read ↗

An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure.Semantic proximity Read ↗

Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynxSemantic proximity Read ↗

Identification of disease-relevant modulators of the SHH pathway in the developing brain.Semantic proximity Read ↗

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.Semantic proximity Read ↗

Ciliary Hedgehog signaling regulates cell survival to build the facial midlineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.