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Article

A deficiency in RFX3 causes hydrocephalus associated with abnormal differentiation of ependymal cells

1 Aug 2006

Abstract excerpt

Ciliated ependymal cells play central functions in the control of cerebrospinal fluid homeostasis in the mammalian brain, and defects in their differentiation or ciliated properties can lead to hydrocephalus. Regulatory factor X (RFX) transcription factors regulate genes required for ciliogenesis in the nematode, drosophila and mammals. We show here that Rfx3-deficient mice suffer from hydrocephalus without...

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PMID: 16930429
DOI: 10.1111/j.1460-9568.2006.05002.x

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